[Skip to Navigation]
May 1955

Use of Large Doses of Cortisone in Schizophrenia: Clinical, Physiological, and Metabolic Observations

Author Affiliations

New York

From the Departments of Clinical Psychiatry and Medicine, New York State Psychiatric Institute.

AMA Arch NeurPsych. 1955;73(5):485-495. doi:10.1001/archneurpsyc.1955.02330110001001

The purpose of this investigation was to assay the effects of large doses of cortisone in known schizophenics, who, for the most part, were resistive to other forms of therapy. Since Hench, Kendall, Slocum, and Polley1 first published their paper in April, 1949, on the use of cortisone in rheumatoid arthritic patients, literally hundreds of investigators have reported on the psychological changes secondary to the administration of cortisone for the treatment of various primary organic and psychosomatic illnesses. In most instances it is difficult to tell whether the psychic changes reported were due to the direct action of the hormone drug itself or represented secondary effects arising from alterations in the organic disease processes.

Relatively few studies were reported on the cortisone treatment of patients with psychiatric disturbances. In 1951, Cohn and associates * reported that cortisone produced very favorable results in some refractory schizophrenic patients. Also, it apparently enhanced