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May 1955

Epinephrine-Mecholyl Test (Funkenstein Test): Its Value in Determining the Recovery Potential of Patients with Mental Disease

AMA Arch NeurPsych. 1955;73(5):496-514. doi:10.1001/archneurpsyc.1955.02330110012002

This paper is based on a study of 201 consecutive patients seen in private practice during the past six years to whom Funkenstein's prognostic test1 was administered prior to treatment. In a number of these patients the test was repeated at intervals during the course of, and after completion of, treatment. The subject of the present paper is the correlation of the pretreatment test results in these 201 cases with the outcome of the therapy chosen. The predictive value of the test was then subjected to statistical analysis.

This material is suited to test and validate the concepts developed by Funkenstein and associates1 and amplified by Gellhorn2 on a new sample.

The Funkenstein test consists in measuring the blood pressure changes and observing the immediate clinical and psychological response of the patient, first to an intravenous injection of 0.025 mg. of epinephrine, then to an intramuscular injection