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May 1955

Nature of Certain Osseous Lesions in Tuberous Sclerosis

Author Affiliations

Caro, Mich.

From the Caro State Hospital for Epileptics.

AMA Arch NeurPsych. 1955;73(5):525-529. doi:10.1001/archneurpsyc.1955.02330110041004

It has been well established that characteristic roentgenographic signs may play a significant part in the diagnosis of the syndrome known as tuberous sclerosis. Recently, Holt and I1 demonstrated that 66% of our patients had definite roentgenographic changes in the phalanges of the hands and feet. A similar incidence has since been found by Berland.2 We pointed out that the histologic nature of these lesions had not been demonstrated, but speculated that "the bone cysts are not cysts at all in the true sense of the word. They probably represent areas of nonspecific fibrous replacement similar to that found in the transient cortical defects of growing tubular bones and certain cystic forms of neurofibromatosis of bone."

This report is concerned with the histologic structure of the lesions found in the terminal phalanges of the hands of a patient suffering from tuberous sclerosis.


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