Tönnies,1 in a review of the literature on the changes in the serum proteins due to tumor growth, notes that a high globulin-to-albumin ratio has been found consistently in association with human cancer. This observation, based upon studies employing the older techniques of protein chemistry, has been confirmed by the newer method of electrophoresis of moving boundaries.2 Janssen,3 also using electrophoretic methods, found an increase in the gamma globulin content of the serum from patients with cancer in the pancreas or liver. Rundles and associates4 found hypoalbuminemia and increases occurring in the various globulin fractions in patients who were seriously ill with chronic lymphocytic leukemia, with chronic granulocytic leukemia, or with acute or subacute leukemia.
More recently, paper electrophoresis has been used for the analysis of serum proteins.* Knedel and Zettel8 applied the method to cases of bronchial carcinoma and found a significant increase in
ROBOZ E, HESS WC, FORSTER FM. Determination of Serum Proteins and Polysaccharides: Comparison of Neoplastic Diseases, Particularly of the Central Nervous System. AMA Arch NeurPsych. 1955;73(5):536–543. doi:10.1001/archneurpsyc.1955.02330110052007
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