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May 1955

Cerebral Oxygen Uptake in Chronic Schizophrenic Reaction

Author Affiliations

San Francisco; Los Angeles; San Francisco; With the Technical Assistance of Edward Martinez, and Patricia McCreary, M.T.

From the Cerebral Metabolic Research Laboratory of the Langley Porter Clinic, State Department of Mental Hygiene, and the Departments of Medicine, Psychiatry, and Neurological Surgery, University of California School of Medicine (aided by a grant from the Multiple Sclerosis Society).

AMA Arch NeurPsych. 1955;73(5):544-545. doi:10.1001/archneurpsyc.1955.02330110060008

Since Kety and associates1 reported that the cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo2) are normal in schizophrenia, patients with this disorder have commonly been used as "normal subjects" for cerebral metabolic studies. In the course of such studies we have noted unusually low values for CMRo2 in approximately one-third of patients with chronic schizophrenic reactions.

Using the original nitrous oxide technique of Kety and Schmidt,* we have made 29 determinations of CBF and CMRo2 upon 24 patients with chronic schizophrenic reactions of two or more years' duration and have compared these with the rates in 81 control cases.

The experimental group consisted of 11 men and 13 women from 16 to 66 years of age, with an average age of 36 years. In these subjects the onset of clearly recognizable schizophrenic reactions had occurred from 2½ to 23 years prior to

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