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June 1955

Antibrain Antibodies in Multiple Sclerosis: Study of the Antibrain Antibodies in the Blood of Multiple Sclerosis Patients by Complement Fixation Tests

Author Affiliations

Dorchester, Mass.

From the Pathological Laboratory and the Multiple Sclerosis Clinic of the Boston State Hospital.

AMA Arch NeurPsych. 1955;73(6):645-655. doi:10.1001/archneurpsyc.1955.02330120049005

This study is based on the premise that the serum of a multiple sclerosis patient may contain antibrain antibodies and that the disease is of an allergic nature. The etiology of multiple sclerosis being unknown, it was thought desirable to explore the possibility of a specific reaction of the blood sera of multiple sclerosis patients with the antigens prepared from the multiple sclerosis brains. Specific serologic studies in multiple sclerosis have been reported by Sachs and Steiner,1 Steiner,2 Frick,* and others. Acute disseminated encephalomyelitis accompanied by production of antibrain antibodies has been induced in animals by injection of emulsions of normal homologous and heterologous brain or spinal cord tissues, with or without adjuvants. † The production of these antibodies in the monkey was reported by Kopeloff and Kopeloff.9 Schwentker and River10 produced antibody response in the rabbits by injections of emulsions of homologous brain. Hill11