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July 1955

Variations in the Plasma Fibrinogen During the Course of Multiple Sclerosis

Author Affiliations


From Nørre Hospital (Chief: Prof. E. Jarløv, M.D.), and the Neurological Department of the Municipal Hospital (Chief: Dr. K. Krabbe, M.D.).

AMA Arch NeurPsych. 1955;74(1):17-30. doi:10.1001/archneurpsyc.1955.02330130019004

The purpose of this work is to assess the values of the plasma fibrinogen found during the course of multiple sclerosis.

On the basis of pathological-anatomical and experimental investigations, Putnam * was the first to advance the theory that in the case of multiple sclerosis thrombi are formed in the small veins of the central nervous system and consequently cause the formation of the characteristic plaques.

Broman4 and Haarr,† on the basis of pathological-anatomical investigations, defined multiple sclerosis as a periphlebitis; however, they were unable to demonstrate coagulation thrombi in plaques in patients with the disease. Through his investigations, Fog5 found that in this disease the plaques of the spinal cord occur in relation to the veins. It is often difficult to distinguish between the acute signs of this disease and those of vascular attacks; moreover, external factors which increase the coagulability of the blood seem to aggravate multiple

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