Reserpine is a crystalline alkaloid isolated from the crude root of Rauwolfia serpentina. The latter drug was used for centuries in native Indian medicine for the treatment of a wide variety of diseases, including mental disorders, but it was introduced into this country for its use in the management of hypertension. Reserpine, isolated in 1952, appears to be the chief active principle of Rauwolfia. The value of resperine in the treatment of disturbed psychiotics has been shown by us in previous papers.* These studies included only a small number of patients with convulsive disorders. However, since there was an indication that such patients did not respond to treatment as well as the others, and since at times the incidence of convulsive seizures seemed to be increased, it was deemed advisable to subject to more intensive study a larger group of patients with convulsive disorders. This study is being reported in
BARSA JA, KLINE NS. Reserpine in the Treatment of Psychotics with Convulsive Disorders. AMA Arch NeurPsych. 1955;74(1):31–35. doi:https://doi.org/10.1001/archneurpsyc.1955.02330130033005
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