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August 1955

Chlorpromazine (Thorazine) Treatment of Disturbed Epileptic Patients: Preliminary Report

Author Affiliations

Sonyea, N. Y.

AMA Arch NeurPsych. 1955;74(2):158-162. doi:10.1001/archneurpsyc.1955.02330140042007

This report covers the treatment of 78 epileptic patients at Craig Colony for a period varying from 30 to 60 days. All of the patients were female, and the group under treatment for the longest period represented the worst, most actively disturbed patients in an institution of 2300 patients. The patients were selected in consultation with the ward physician, ward supervisor, and other ward personnel, and the method of selection was simply, "Name your 50 most troublesome patients." All of these patients lived in a closed service and were allowed to continue their daily activities as before. Later, additional cases were added. All were kept under close observation, and laboratory studies were undertaken when indicated by clinical judgment.

Behavior difficulties were characterized by episodic disturbed states and chronic disturbed states, involving hyperactivity, aggression, hostility, assaultiveness, noisiness, resistiveness, temper outbursts, furor states, and destructiveness. Many frequently required large doses of sedation

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