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October 1955

The Effect of Hydrocortisone on the Healing of Wounds of the Brain: An Experimental Study on the Cat

Author Affiliations

México, D.F.

From the Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute, Montreal, Canada.

AMA Arch NeurPsych. 1955;74(4):407-413. doi:10.1001/archneurpsyc.1955.02330160057008

The literature concerning the effects of the adrenal steroids cortisone and hydrocortisone on tissues and systems is exhaustive. Hydrocortisone U. S. P. (17-hydroxycorticosterone; Compound F) has been reported to be more potent, milligram by milligram, than cortisone,1 and the main physiologic actions of the two are similar.2 Hydrocortisone used in local application allows a higher concentration of the hormone in the tissue, and the difference in local effectiveness as compared with that of cortisone remains unexplained.3

Wound healing is delayed by cortisone,* and several tissues have been reported to be affected in the healing process when the adrenocortical steroid is given in high doses parenterally,7 by local application, by subcutaneous injection,8 or subconjunctivally.†

The action of cortisone in the healing of the central nervous system as noted experimentally has been observed to be a depression of the early inflammatory phase in puncture wounds of the

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