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October 1955

Cerebrospinal Fluid Inorganic Phosphorus in Normal and Pathologic Conditions

Author Affiliations

Haifa, Israel; Chicago

From the Dr. Julian D. Levinson Research Foundation; the Children's Division of the Cook County Hospital, and the Hektoen Institute for Medical Research.

AMA Arch NeurPsych. 1955;74(4):424-440. doi:10.1001/archneurpsyc.1955.02330160074010

Phosphorus is the most important mineral constituent of nerve tissue, of both the white matter and the gray matter.1 In view of this, it is conceivable that histologic changes in the brain substance might be reflected by a change in the inorganic phosphorus level of the cerebrospinal fluid. It is no wonder, therefore, that the study of the inorganic phosphorus of cerebrospinal fluid, in normal and in pathologic conditions of the central nervous system, has aroused considerable interest. In spite of this, however, this chapter is far from closed.

The results of the various studies on this subject seem to be fairly consistent as regards the normal range of cerebrospinal fluid inorganic phosphorus. Elevated values have also been consistently reported in a number of pathologic conditions. In other pathologic conditions, however, the results of various investigators are rather conflicting. Nor has unanimity been reached on the subject of the