This paper is a report on a controlled study which extended over a period of eight months using the drug reserpine. Reserpine (Serpasil) offers many of the advantages of present pharmaceutical techniques without incurring many of the liabilities. It acts as a tranquilizer, quieting the patients but leaving their sensorium clear and clouding consciousness but little. Its primary use appears to be in quieting agitated and disturbing patients. We feel that it in no way affects the psychosis itself.
The most exacting test of the effectiveness of this drug would be in using it with chronic, severely disturbed and agitated patients who had failed to improve under the usual regime of treatment, such as insulin coma therapy and electroconvulsive therapy. This would be not only a definitive measure of drug effectiveness but also the most reliable measure. Any improvement shown could then definitely be considered a result of the treatment,
COWDEN RC, ZAX M, SPROLES JA. Reserpine: Alone and As an Adjunct to Psychotherapy in the Treatment of Schizophrenia. AMA Arch NeurPsych. 1955;74(5):518–522. doi:10.1001/archneurpsyc.1955.02330170052009
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