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In this volume is reported a detailed clinical and laboratory study of 150 patients with mental disorders subjected to lobotomy at the Toronto Psychiatric Hospital during the years 1948 to 1952. The objective was to determine what factors were predictive of a good result. There were many good results; indeed, 55% of the patients were out of hospital and functioning reasonably well a year after operation. Since the patients had been hospitalized for an average of five years, these clinical results are outstanding. However, there was no single item, and, indeed, no group of items, that made for any very reliable prognosis. Even duration of hospitalization was considered of no great importance. This factor is suspect, however, since so few of the patients were operated upon before the five-year period had elapsed. Prediction was based upon a quantitative scale, where zero represented the patient who was a constant nursing problem,