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January 1956

Procaine Oil Blocking of the Globus Pattidus

Author Affiliations


From the Department of Neurology and Psychiatry, Tokyo University School of Medicine.

AMA Arch NeurPsych. 1956;75(1):36-48. doi:10.1001/archneurpsyc.1956.02330190052003

In about six years' use of the stereotactic operation in this laboratory, during which the first, second, and third models of the stereoencephalotome were completed, our main concern has been the globus pallidus and the thalamus. Several reports have previously been published on the technique used and the earlier results.

In this paper, the treatment of rigidity and tremor of Parkinsonism, using a stereotactic injection of procaine HCl in oil and wax, will be described and discussed. We believe that stereoencephalotomy, in addition to the opportunities for treatment that it offers, provides an approach to an investigation of the function of the subcortical ganglia.

Since James Parkinson described paralysis agitans (Parkinson's disease) as a senile disorder in 1817, the neuropathology of this disease has been studied by many investigators. At first this disease was thought of as a senile process for which a hereditary predisposition was assumed. But after the

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