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January 1956

Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey

Author Affiliations

Bethesda, Md.

AMA Arch NeurPsych. 1956;75(1):49-53. doi:10.1001/archneurpsyc.1956.02330190065004

INTRODUCTION  Bufotenine (5 -hydroxy -3 -[2- dimethyl-aminoethyl]-indole) is the N-dimethyl derivative of the vasoconstrictor substance serotonin (5-hydroxytryptamine). It was first synthesized by Wieland in 1934. Raymond-Hamet found that intravenous injection of bufotenine caused transient elevation of blood pressure and apnea, followed by tachypnea, in anesthetized dogs.* To date, however, there is little published material concerning the effects of bufotenine on unanesthetized animals. Our interest in such effects was based on the fact that bufotenine was recently isolated from the bean of Piptadenia peregrina,5 a bean long known to be the source of cohoba, a narcotic snuff. This snuff has been used by inhabitants of the West Indies to induce hallucinations and mystical states,6 states which seem similar to those produced by mescaline, harmine, and lysergic acid diethylamide. It was felt, in view of the reported psychological effects of bufotenine-containing snuff, that it would be worth while to investigate

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