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May 1956

Comparison of Chlorpromazine and Reserpine in Treatment of Schizophrenia: A Study of Four Hundred Cases

AMA Arch NeurPsych. 1956;75(5):510-513. doi:10.1001/archneurpsyc.1956.02330230060006

INTRODUCTION  In the few years since the introduction of chlorpromazine * and reserpine † in the treatment of schizophrenia, there have been a great many reports relating to their effectiveness. A sampling of such reports ‡ confronts the investigator with a multiplicity of rating scales. In an effort to construct some base line against which our observations and clinical experiences could be compared, a series of tables were drawn up from these reports dealing with the effect of chlorpromazine and reserpine in schizophrenic patients hospitalized six months or longer, who had been exposed to treatment for a period of three weeks and longer.In order to construct Tables 1, 2, and 3 from the reports utilized, the patients listed as discharged or in a state of remission were all included in the category of "Marked Improvement." A comparison of Tables 1 and 2 from the reports surveyed reveals both drugs as

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