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June 1956

Behavioral Changes of Chronic Schizophrenics in Response to Reserpine

Author Affiliations

Salt Lake City

From the Veterans Administration Hospital, Fort Douglas Division, Salt Lake City.

AMA Arch NeurPsych. 1956;75(6):575-578. doi:10.1001/archneurpsyc.1956.02330240013001

PURPOSE OF STUDY  This study has to do with the action of reserpine on the behavior of chronic schizophrenics. It is reported because of the experimental design employed, despite the risk of repeating the conclusions of many similar studies. The study was designed with the thought that only one major variable (reserpine *) was desirable, i. e., that the validity of results should not be lessened by the fact that either the raters who evaluated the behavior change of the patients or the patients themselves had any information concerning the identity of the drug group. For this reason, a double-blind design was used, with adequate experimental and control groups.

PROCEDURE  A ward of 27 chronic schizophrenics, average hospitalization nine years, was selected for study, because as judged both by the estimate of their situation and by testing devices there had been no appreciable change in their behavior in over three to

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