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July 1956

Action of Local Hydrocortisone on Spinal Cord Wounds: Effect on Inflammation, Repair, Degeneration, and Regeneration

Author Affiliations

Montreal, Canada

From the Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute, reprint no. 531.

AMA Arch NeurPsych. 1956;76(1):34-41. doi:10.1001/archneurpsyc.1956.02330250036005

The general systemic effects of adrenocortical steroids is not a primary factor in the delayed healing and diminished inflammatory phenomena of wounds. A primary action of these hormones on the connective tissue elements is now accepted.1

The anti-inflammatory action of hydrocortisone may be due to the protection of the mesodermal elements from the injured tissue in the wound.2 The anti-inflammatory properties have been explained by a direct action on the fibroblast cell,3 interference with the elaboration of ground substance,4 and, mainly, alteration in the permeability of the vessels.* The effects on inflammation and repair of local application of hydrocortisone acetate to wounds of the brain and to other parts of the body are similar. The cerebral cicatrix is diminished and proliferation of connective tissue is depressed, as compared with a contralateral wound, at corresponding periods of time, in the same animal.6

The action of local

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