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August 1956

Comparison of Reserpine and Placebo in Treatment of Psychiatric Outpatients

Author Affiliations


From the Department of Psychiatry, The Johns Hopkins University School of Medicine.

AMA Arch NeurPsych. 1956;76(2):207-214. doi:10.1001/archneurpsyc.1956.02330260093010

Introduction  In the functioning of a psychiatric outpatient department in a large city, where the community needs for psychiatric care are considerably greater than the resources of the clinic to deal with them psychotherapeutically, we are constantly concerned with the discovery and development of additional methods and means of helping emotionally sick people. Recent work at Yale,1 confirmed for our population at this clinic,2 has pointed up the marked difficulties in attempting to deal with psychiatrically unsophisticated persons of lower socioeconomic class by psychotherapeutic means. The use of drugs in the management of many patients has long been a customary practice and has yielded varying, and often highly personalized, clinical impressions of their efficacy.With the discovery of the "tranquilizing" effects of reserpine in hypertensive patients3 and in psychotic patients,4 and with the knowledge of the toxic effects of the drug, it became, therefore, of interest