That the Guillain-Barré syndrome may, at least in some instances, be a manifestation of hypersensitivity has been suggested by several writers.* Association of this syndrome and other clinical manifestations of hypersensitivity has been reported in cases following administration of serum and typhoid-paratyphoid (T.A.B.) vaccine.† The case to be described exhibited nonthrombocytopenic purpura, arthritis, and edema in association with the syndrome following upon a streptococcal skin infection. To our knowledge it appears to be the first instance of this nature.
Report of a Case
A married, well-built, well-nourished housewife, aged 41, was admitted to the hospital on Nov. 7, 1955, with complaints of shooting pains in all four limbs and marked weakness, pain in the joints, edema of the face and arms, and extensive subcutaneous hemorrhages. The illness had started on Oct. 5, 1955, with slight swelling and pain in the joints and puffiness of the face and arms. A week