[Skip to Content]
[Skip to Content Landing]
November 1956

Effects of Chlorpromazine on Chronic Lobotomized Schizophrenic Patients: A Controlled Study

Author Affiliations

Worcester, Mass.

AMA Arch NeurPsych. 1956;76(5):500-507. doi:10.1001/archneurpsyc.1956.02330290044005

There have been numerous articles attesting to the therapeutic efficiency of chlorpromazine in psychoses. There has also been a notable dearth of controlled studies utilizing placeboes to evaluate the role of the enthusiasm of the psychiatrist, the ward personnel, and the patients themselves. A search of the literature has noted only two, those of Gardner, Hawkins, Judah, and Murphree1 and of Kovitz, Carter, and Addison,2 both dealing with chronic schizophrenic patients.

The present study is of the double-blind variety, in which the effects of chlorpromazine and placeboes on two matched groups of chronic schizophrenic patients were noted. It was not intended, primarily, as a therapeutic investigation but was organized to determine the threshold dose of the drug which would produce an effect distinguishable from that obtained on administering placeboes.

Method and Material  The technique used in evaluating the status of the patients was as follows: After an interview,