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November 1956

Multiple Sclerosis

AMA Arch NeurPsych. 1956;76(5):512. doi:10.1001/archneurpsyc.1956.02330290056009

This volume was written by a neurologist in collaboration with a general practitioner and a pathologist. The three main objectives stated in the preface are "first to widen the general conception of the disease; secondly to provide an account of the early symptomatology and treatment; and thirdly to review the pathology and the relationship of multiple sclerosis to other dymyelinating diseases."

Each of these objectives is fulfilled. Various etiological factors are reviewed, as well as the theories of etiological mechanisms. A large section is devoted to the early symptomatology of the disease, emphasizing that it is the pattern of the behavior that renders multiple sclerosis unique. Clinical observations on the local spread of the disease are recorded and discussed. The cerebrospinal fluid is analyzed in respect to cells, protein, and colloidal reactions, along with the electrophoretic and immunochemical methods of quantitative analysis. The course of the disease is reviewed and

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