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December 1956

Lipoprotein Patterns of Spinal Fluid Obtained by Paper Electrophoresis

Author Affiliations

Oakland, Calif.

From the Neurology and Laboratory Services, Veterans Administration Hospital.

AMA Arch NeurPsych. 1956;76(6):608-613. doi:10.1001/archneurpsyc.1956.02330300038005

Introduction  Recent studies of lipids in multiple sclerosis derive from at least two lines of thought, which may perhaps eventually converge. One is the theory that a fault in lipid metabolism may be involved. Swank * is one of the proponents of this argument, and he has extended his theory into practice by advocating a low-fat diet. Other investigations on the serum lipids in multiple sclerosis, however, have agreed in finding little evidence for a quantitative abnormality in the cholesterol, phospholipids, or lipoproteins.† The second approach is based on the search for breakdown products of myelin in the spinal fluid. Myelin is a lipoprotein complex whose exact chemical analysis has not yet been accomplished. One possible way to find out how the myelin is destroyed would be to identify its breakdown products. This, then, would offer some indication as to location or type of bond which had been disrupted. The present

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