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January 1957

Long-Term Effects of Phensuximide (Milontin)

AMA Arch NeurPsych. 1957;77(1):23-27. doi:10.1001/archneurpsyc.1957.02330310033004

Davidson, Lombroso, and Markham1 have reported the effect of phensuximide (Milontin) in a group of 249 patients seen in the Seizure Unit of the Children's Medical Center in Boston. Their evaluation was completed in June, 1953, at which time their patients had been receiving phensuximide for one to three years. Zimmerman,2 who pioneered in the use of this drug, reported that after an interval of 15 months the percentage of completely controlled cases had dropped from 30 to 21.3 Therefore, we deemed it wise to restudy the longer-term effect of medication and to check the occurrence of microscopic hematuria observed by Millichap.4

Method of Study  All patients had been seen, as clinic or office patients, in the Seizure Unit, when first placed on phensuximide. Most of them have been followed regularly since that time. As mentioned in the report of Davidson and associates,1 the series