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March 1957

Chlorpromazine (Thorazine) Treatment of Disturbed Epileptic Patients

Author Affiliations

Sonyea, N. Y.

AMA Arch NeurPsych. 1957;77(3):243-246. doi:10.1001/archneurpsyc.1957.02330330029003

One hundred sixty-five disturbed epileptics of ages from 3 to 69 years have been treated at Craig Colony with chlorpromazine for periods varying from 2 to 12 months, the majority of whom are female. This series includes a group of 78 patients on whom a preliminary report1 was submitted about a year ago and a supplemental group of 87 patients. The length of treatment is shown in Table 1.

Selection for therapy was based on behavior and emotional disturbances, episodic and chronic, clinically manifested by irritability, excitement states, temper outbursts, furor states, restlessness, overactivity, resistiveness, destructiveness, assaultiveness, nakedness, aggression (such as biting, scratching, and pulling hair of self and others), self-mutilation, noisiness, profanity, night wandering, filthy habits, and active psychotic trends. Many frequently required large doses of sedation or some form of restraint or seclusion. The overwhelming

majority of patients are mentally defective, with 21 idiots, 47 imbeciles, 46

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