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April 1957

Studies on the Diethylamide of Lysergic Acid (LSD-25): II. Effects of Chlorpromazine, Azacyclonol, and Reserpine on the Intensity of the LSD-Reaction

Author Affiliations

Lexington, Ky.

From the National Institute of Mental Health, Addiction Research Center, U. S. Public Health Service Hospital.

AMA Arch NeurPsych. 1957;77(4):350-358. doi:10.1001/archneurpsyc.1957.02330340026002

The effects of "tranquilizing" drugs on the abnormal mental state induced by the diethylamide of lysergic acid (LSD-25) are of interest from several points of view. Some means of mitigating too severe a reaction is needed in using LSD-25 experimentally or therapeutically. Since the LSD reaction is measurable and reproducible,1 it might be possible to use the LSD psychosis as a screen for predicting the potential clinical value of new tranquilizing drugs. In addition, such studies might be useful in elucidating the mechanisms of action of both the tranquilizers and the psychotogenic drugs. The purpose of the present paper is to present the results of experiments in which attempts were made to block (prevent) or reverse (treat) the LSD reaction with chlorpromazine, azacyclonol (Frenquel), and reserpine.


Subjects.—  The subjects used in these experiments were all adult male drug addicts who were serving sentences for violation of the Harrison

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