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May 1957

Thyroid Activity in Hospitalized Psychiatric Patients: Relation of Dietary Iodine to I131 Uptake

Author Affiliations

Vermillion, S. D.

From the Department of Physiology and Pharmacology, University of South Dakota School of Medical Sciences.

AMA Arch NeurPsych. 1957;77(5):543-548. doi:10.1001/archneurpsyc.1957.02330350109017

Introduction  A number of investigators have reported abnormalities in thyroid function in mental patients. Thus, Farr,1 Walker,2 and Bowman and Fry3 concluded that basal metabolic rates tended to be low in schizophrenic patients. Brody found normal levels of protein-bound iodine in 125 psychiatric patients without clinical thyroid disease. However, he felt there were small but significant differences between patients with higher and those with lower levels of tension.4 Bowman and his associates reported increased thyroid uptake of radioactive iodine and normal protein-bound iodine in schizophrenics.5 Cranswick confirmed Bowman's findings of elevated thyroid uptakes and lowered B. M. R.'s in schizophrenics and additionally noted in these patients an apparent unresponsiveness to hypophyseal thyroid-stimulating hormone.6 Reiss, by tracer I131 methods before and after treatment, found a significant correlation between changes in mentation and thyroid function7 which he felt was a reflection of more extensive

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