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September 1957

Effects of Lysergic Acid Diethylamide (LSD) on the Time Sense of NormalsA Preliminary Report

Author Affiliations

Houston, Texas

From the M. D. Anderson Department of Psychiatry, Baylor University College of Medicine, Texas Medical Center.

AMA Arch NeurPsych. 1957;78(3):321-324. doi:10.1001/archneurpsyc.1957.02330390103013

Introduction  Much of the interest in lysergic acid diethylamide (LSD) is due to its capacity to produce schizophrenic-like behavior when administered in extremely small quantities.4,6 Among the reported changes resulting from LSD have been alterations in time perception. DeShon, Rinkel, and Solomon,1 found changes in the form of experiences of acceleration, retardation, or nonexistence of time, while "true disorientation" was not observed. The subjects of Hoch, Cattell, and Pennes3 reported the passage of time as slowed, an experience not uncommon to schizophrenic patients.An objective study of the time sense of schizophrenics5 indicated that this population overestimates short audible durations to a significantly greater degree than do normal controls. The purpose of the present investigation was to determine whether moderate to low doses of LSD produce alterations in the time sense of normal subjects in the direction characteristic of schizophrenia, using the same method as reported