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November 1957

Effect of Synthetic Diet Low in Aromatic Amino Acids on Schizophrenic Patients

AMA Arch NeurPsych. 1957;78(5):539-542. doi:10.1001/archneurpsyc.1957.02330410103015

This paper describes the effects on young hospitalized schizophrenic patients of a diet essentially free of aromatic amino acids. The metabolic effects of such a diet, as reflected in the content of "aromatic" compounds in blood and in their excretion in the urine, form the subject of a separate communication. The present paper will be concerned only with the clinical changes observed in the patients.


Patients Studied.—  Twelve female and eleven male patients were selected at random by the clinical chiefs of service with the following criteria in mind: 1. They were to be less than 35 years of age. Four were in their late teens; two were 31 and 38, respectively, and the rest were in their 20's. 2. Patients were sought who had recovered from previous acute psychotic episodes in hospital, so that more information might be available regarding their behavior during these periods, and that as