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January 1958

Etiology and Pathogenesis of Laminar Cortical Necrosis: Its Significance in Evaluation of Uniform Cortical Atrophies of Early Life

Author Affiliations

Los Angeles

From the Department of Nervous Diseases (Neuropathology), College of Medical Evangelists, and the Cajal Laboratory of Neuropathology, Los Angeles County Hospital.

AMA Arch NeurPsych. 1958;79(1):7-30. doi:10.1001/archneurpsyc.1958.02340010025002

One of the characteristic tissue responses found in the brain is that which affects selectively and to varying degrees one or more of the cellular laminations of the cerebral cortex. This lesion has been described under varying names, but is best known in the older literature as "status spongiosus," and more recently as "laminar (or pseudolaminar) necrosis." As the name implies, one or more strata of the cortex are altered more or less profoundly over appreciable extents of the covering gray ribbon, sufficiently to constitute a conspicuous architectural alteration.

It is my purpose to review briefly the history of this characteristic alteration, to note the development of concepts as to its etiology, to amplify its pertinent qualities in order to understand the total picture involved, to make clear its relation to the larger problem of cerebral anoxia, and to point out its importance as a significant feature of a group

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