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February 1958

Effect of Cortisone upon Spinal Cord Regeneration in Adult Rat

AMA Arch NeurPsych. 1958;79(2):170-174. doi:10.1001/archneurpsyc.1958.02340020050009
Abstract

Despite recent advances in caring for the neurologically crippled patient, there has been little progress in preventing permanent loss of function when tissue of the central nervous system is severely injured. The problem remains one of a lack of regeneration when central nerve fibers are completely destroyed. The present investigation was undertaken to determine whether cortisone would have a favorable influence upon the healing of a completely severed spinal cord.

Although not commonly recognized, there appears to be a natural inclination for the regeneration of severed central nerve fibers. This observation was first made by Ramón y Cajal,1 who described an abortive growth of these structures after severance, the fibers appearing to be blocked in their growth by the formation of a fibrous and glial tissue barrier at the site of injury.

Windle, Clemente, Scott, and Chambers2 reported histologic and electrophysiologic evidence of intraspinal regeneration following complete transection

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