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March 1958

Generalized Moniliasis with Localization in the Brain

AMA Arch NeurPsych. 1958;79(3):250-263. doi:10.1001/archneurpsyc.1958.02340030014002

Generalized Moniliasis Before Introduction of Antibiotic Therapy  With the widespread employment of broad-spectrum antibiotics the incidence of generalized monilial infections involving the central nervous system has markedly increased. Nevertheless, no detailed description has yet to our knowledge been made of the histological changes caused within the brain by Candida albicans.The yeast-like fungus C. albicans was discovered in oral thrush by Langenbeck in 1839 and first described by Robin under the name of Oidium albicans in 1853. Over 170 synonyms exist for it today (Mohr1). Experiments conducted by Benham showed that of the various species of Candida, C. albicans is the only one important in human pathology.C. albicans is widely distributed in nature and can often be found under normal circumstances as a harmless saprophyte in the oropharynx, the intestinal tract, and the vagina. Before the introduction and universal employment of antibiotic therapy, generalized infections with Candida were