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April 1958

Effectiveness of Insulin Coma in the Treatment of Schizophrenia: A Control Study

Author Affiliations

Middletown, Conn.

AMA Arch NeurPsych. 1958;79(4):460-467. doi:10.1001/archneurpsyc.1958.02340040104011

Introduction  The present study was undertaken in an effort to learn whether insulin coma therapy (ICT) per se had any effect in bringing about an improvement in cases of schizophrenia. This was an attempt to compare groups of truly similar patients in a setting where the only large variable would be the insulin itself. For this purpose it was necessary that all patients be placed directly in the insulin environment and subjected to the same procedures. The methods will be discussed later.The literature concerning the validity of insulin coma therapy is extensive, and the variety of resulting conclusions about the problem is just as extensive. Investigators have concluded that ICT itself is of definite benefit in the treatment of schizophrenia,1-3 that insulin coma is of no advantage,4,5 or that it may possibly be a detriment.The inconsistency of these results may have resulted from one or more