Investigations into the function of the adrenal glands in schizophrenia have not yielded uniform results (Altschule1). The finding of adrenal unresponsiveness by Hoagland et al.4 has in general been confirmed by other workers, such as Hemphill and Reiss3 and Faurbye et al.2 However, these workers used chronic cases for the most part, in which all physiological changes are difficult to evaluate.
Hoagland et al.5 have reported that improvement with EST is correlated with the responsivity of the adrenal cortex, as determined by test injections of corticotropin given to the patient prior to his course of shocks. They found that the more normal the responsivity of the schizophrenic adrenal was to corticotropin the better the subsequent prognosis when the patient was given EST. Pincus and associates6 also came to the conclusion there was a relationship between the responsivity of the adrenal cortex and the schizophrenic
SHEARD MH. Responsivity of Adrenal Gland in Schizophrenia to Corticotropin. AMA Arch NeurPsych. 1958;79(6):727–729. doi:https://doi.org/10.1001/archneurpsyc.1958.02340060125018
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