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August 1958

Serum Aldolase in Muscular Dystrophies, Neuromuscular Disorders, and Wasting of Skeletal Muscle

Author Affiliations

New York

From the Division of Neurology and the Laboratory Division, Montefiore Hospital, and the Department of Neurology, Columbia University College of Physicians and Surgeons.

AMA Arch NeurPsych. 1958;80(2):157-161. doi:10.1001/archneurpsyc.1958.02340080027003

In 1953 and 1954, the Schapiras, Dreyfus, and Kruh8,9 reported that the concentration of serum aldolase was consistently elevated in patients with muscular dystrophy. Because of the potential importance of such a diagnostic test, we have attempted to evaluate this finding. While the present study was in progress, reports by Jacob and Neuhaus,5 Aronson and Volk,1 and Beckmann2 appeared which confirmed the original description.

Methods and Material 

Serum Aldolase.—  The method employed for the determination of serum aldolase activity was essentially that of Sibley and Lehninger.10,11 Only minor modifications were introduced. Sibley and Lehninger reported their results in terms of the number of cubic millimeters of hexose diphosphate substrate split per hour at 38 C (cu. mm. HDP/ml/hr.) in order to make their values comparable to the commonly used Q notation, in which Q (substrate) = (cubic millimeters of substrate acted upon)/(milligrams of dry tissue multiplied

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