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August 1958

Blood Glutathione Levels in the Male Schizophrenic Patient

Author Affiliations


From the Medical Research Laboratory and Neuropsychiatric Service, Veterans' Administration Hospital.

AMA Arch NeurPsych. 1958;80(2):237-240. doi:10.1001/archneurpsyc.1958.02340080107023

In a recent review by Patterson and Lazarow1 on the determination of reduced glutathione (GSH), the authors show that 10 different methods have been used in the analysis for glutathione. These authors state that the most widely used method is the iodometric titration method, and they go into some detail in describing this method, as well as the glyoxalase method and the alloxan "305" method.

Recently Martens2 and Angel3 and their associates have reported that the blood GSH levels in schizophrenic patients are significantly lower than those found in normal subjects. Previously Altschule et al.4-6 had also reported that the patient with schizophrenia had levels of blood glutathione in or below his lower normal range

The GSH indexes (milligrams per 100 ml. of red blood cells) in schizophrenics reported by Altschule et al.4-6 vary from 10 to 50, with an average value of 34. These values