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August 1958

Continued Meprobamate and Proclorperazine Administration and Behavior

Author Affiliations

Ann Arbor, Mich.

AMA Arch NeurPsych. 1958;80(2):247-252. doi:10.1001/archneurpsyc.1958.02340080117025

In a previous study it was found that meprobamate had no adverse effect on the performance of normal subjects as measured by several tests of sensory, motor, and complex functions. The dose was 800 mg., which is twice the usual clinical dose. The tests were designed to sample several important everyday tasks, such as driving an automobile, that might be affected by a tranquilizer. Out of 21 variables measured, palmar sweat was the only one that showed a statistically significant change with meprobamate.

The present investigation extends in several directions the earlier study of the effects of meprobamate on behavior. First, instead of a single dose, there was chronic administration of the drug. Because most patients use a tranquilizer for a prolonged period, it is clearly important to test for any possible effects of continued use. Second, many more behavioral tests were used. Extensive sampling of many different kinds of