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August 1958


AMA Arch NeurPsych. 1958;80(2):252. doi:10.1001/archneurpsyc.1958.02340080122026

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After the present paper went to press, our attention was called to the recent article by T. A. Loomis and T. C. West, Comparative Sedative Effects of a Barbiturate and Some Tranquilizer Drugs on Normal Subjects (J. Pharmacol. & Exper. Therap. 122:525-531, 1958). They found that meprobamate, chlorpromazine, and secobarbital produced a significant impairment of performance on a simulated automobile-driving apparatus. Phenaglycodol and placebo did not. Loomis and West maintained that they obtained positive results (which we, as well as other investigators, did not) because, among other things, their subjects were more thoroughly trained and their driving task was more difficult. These factors are quite possibly of real importance. Certain questions, however, may be raised about their study: 1. What is the general significance of a research in this field with only eight subjects, especially since analysis of variance showed a markedly significant difference among subjects (P<0.001) and interactions

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