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September 1958

Lysergic Acid Diethylamide (LSD-25)XXV. Effect of Potassium Cyanide and Other Oxidase and Respiratory Inhibitors on the Siamese Fighting Fish

Author Affiliations

New York

From the Biological Laboratory, Cold Spring Harbor, Long Island, N. Y.

AMA Arch NeurPsych. 1958;80(3):345-350. doi:10.1001/archneurpsyc.1958.02340090081013
Abstract

Although it is known that lysergic acid diethylamide (LSD-25) enters the brain, the mechanism by which LSD-25 acts to produce the psychotic patterns in man is unknown. Experiments which are designed to investigate the brain process in the intact animal might lead to a concept that could be developed to study the chemical process originating or connected with clinically occurring schizophrenia.

We have recently been studying the effect of potassium cyanide, sodium azide, hydrazine, and oxygen lack, among other respiration inhibitors, on an intact animal, the Siamese fighting fish. In addition, the action of oxidation-reduction indicators, like methylene blue, Bindschedler's green, and other dye systems, has been explored. It has previously been shown that the behavior of the Siamese fighting fish changes markedly in the presence of small doses of LSD-25 in the surrounding water.1-3 It may now be reported that KCN and sodium azide act on the Siamese

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