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October 1958

Effects of Lysergic Acid Diethylamide (LSD-25) on Intellectual Functions

AMA Arch NeurPsych. 1958;80(4):477-480. doi:10.1001/archneurpsyc.1958.02340100077018

I. Memory 

Introduction.  —The results of previous studies of the effect of lysergic acid diethylamide (LSD-25) on memory suggest that the minimal dose level at which impairment becomes evident lies somewhere between 50μg. and 100μg. Sloane and Lovett Doust,1 working at the 40μg. level, and Jarvik et al.,2 working at the 50μg. level, found little or no evidence of memory impairment in their studies. However, the latter investigators reported that when the dose level was raised to 100μg., scores were significantly lower on four of the five visual tests and on two of the four auditory tests that they employed. Bercel et al.,3 who used 1μg/kg. body weight, also found evidence of impairment, but they studied memory for only one kind of material, a series of unrelated test words. The purpose of the present study was to determine whether memory for various kinds of material is differentially