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November 1958

Evoked Electrical Activity of the Brain During Hypothermia: The Visual System

Author Affiliations

Bethesda, Md.

AMA Arch NeurPsych. 1958;80(5):554-561. doi:10.1001/archneurpsyc.1958.02340110024003

Introduction  Despite the widespread clinical usage of hypothermia, information relative to nervous system activity during hypothermia has been slow to accumulate. This lack of data is somewhat surprising, in that one most important effect of lowering the body temperature is to reduce the metabolic rate of neural tissue.1-4 This reduction serves as a protective influence against the consequences of hypoxia following the extended occlusion of the blood supply to the brain and/or spinal cord during surgical procedures on the heart, brain, great vessels, etc.5-7 The few studies which have been reported have been confined to the investigation of the electrical activity of peripheral nerves or differentially cooled segments of the nervous system, or they have been done under conditions not consistent with the methods employed currently in the clinical management of hypothermia.8-12 Therefore, this investigation was undertaken to evaluate the effect of temperature upon evoked electrical activity