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December 1958

Cerebral Edema and Electroencephalographic Changes After Local Acute Closed Cerebral Injury

Author Affiliations


From the Rush Departments of Pathology, Psychiatry and Surgery, Presbyterian-St. Luke's Hospital.

AMA Arch NeurPsych. 1958;80(6):696-707. doi:10.1001/archneurpsyc.1958.02340120032005

Introduction  Changes in the electrical activity1-7 and water content of the brain8-10 following experimental cerebral injury have been the subject of extensive study. However, most methods used in production of closed lesions have not permitted accurate definition of either the site or the extent of the damage. Investigators, therefore, could not be certain that the observed changes were due entirely to a local lesion. If, on the other hand, the skull was opened to permit selective placement of the lesion,11,12 the undesirable and variable effects of surgical exposure of the brain ordinarily interfered with interpretation of the results. These effects were particularly troublesome in a study of cerebral edema, since circulatory and osmotic changes in the brain due to surgical trauma incidental to craniotomy could not be distinguished quantitatively from the changes due to the experimental lesion itself.13,14In order to avoid difficulties incidental to operative

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