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December 1958

Effectiveness of Dithiazanine Against Worm Infections of Mental Patients

Author Affiliations

Columbia, S. C.

AMA Arch NeurPsych. 1958;80(6):785-787. doi:10.1001/archneurpsyc.1958.02340120121019

Recently Frye, Swartzwelder, et. al.2 (1957) and Swartzwelder, Frye, et al.1 (1957) reported that dithiazanine, a cyanine dye, was therapeutic against trichuriasis, strongyloidiasis, ascariasis, and enterobiasis (oxyuriasis), and exerted significant activity against hookworm.

Parasitic infections are often severe in mental patients, and the elimination of these infections has proved to be very difficult. The encouraging reports on dithiazanine led to its use here to determine its efficacy against parasitic infections in mental patients.

Materials and Methods  The patients were white women who had been at the hospital for several years. Because of mental deterioration, they were unhygienic in their habits. The average weight was about 54 kg. (120 lb.).The presence of infections was determined by direct saline and iodine fecal smears and zinc sulfate centrifugal flotation. The intensity of infection was determined by Stoll egg counts. Two stool specimens were obtained from each patient during the week