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January 1959

Comparison of Two Phenothiazine Derivatives and a Barbiturate in Chronic Schizophrenia

AMA Arch NeurPsych. 1959;81(1):97-99. doi:10.1001/archneurpsyc.1959.02340130117017

Introduction  A prevailing problem in state mental hospitals continues to be the chronic schizophrenic patient, in spite of the increased ease of management which has accompanied the introduction of the tranquilizers. Several phenothiazine derivatives are available and are recommended for such patients.This study was initiated in August, 1956, as a double-blind procedure to compare the effects of two widely used phenothiazine derivatives (chlorpromazine and promazine) in the same group of chronic patients. To determine what alterations in behavior were due to spontaneous change, to the added attention of being interviewed, and to receiving a medication, an identical inactive placebo was included. Finally, to evaluate the effects of a previous tranquilizer which has fallen from favor, a barbiturate was included.It was hoped that further information could be gained as to which similar-appearing chronic patients might show a greater likelihood of improving when treated with different tranquilizers. Too, it seemed