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February 1959

Studies with a New Hallucinogen: Some Dosage-Response Data for JB 318

Author Affiliations


From the Departments of Preventive Medicine and Psychiatry, University of Illinois College of Medicine.

AMA Arch NeurPsych. 1959;81(2):256-263. doi:10.1001/archneurpsyc.1959.02340140122015

Introduction  Previous reports indicated the structure and briefly described the effects of a new group of hallucinogens.1,2 Sufficient experience with one of these, N-ethyl-3-piperidyl benzilate hydrochloride (JB 318), has accumulated such that dosage-response data may be presented. The present communication aims to describe more fully the effects of this agent in humans and to illuminate the relationship between its somatic and its psychologic actions.

Methods  A total of 42 observations were carried out on 39 subjects, 15 of whom were from a heterogeneous nonvolunteer group of clinic or convalescing hospital patients, and the remaining 24 were volunteer medical or divinity students or nurses, or laboratory or other hospital personnel. None was psychotic or exhibited major neurotic symptoms. All subjects were between 21 and 43 years of age; 22 were men, and 33 Caucasian. The patients were unaware of the potential effects of the compound when it was administered, but