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March 1959

A Mental Syndrome Associated with Lung Carcinoma

Author Affiliations


From the Royal Edinburgh Hospital for Mental and Nervous Disorders, Craig House Section.

AMA Arch NeurPsych. 1959;81(3):341-347. doi:10.1001/archneurpsyc.1959.02340150073008

The neurological disorders which may occur in association with carcinoma, in the absence of demonstrable metastatic deposits in nervous tissues, have aroused increasing interest in recent years. The combination of sensory neuropathy and bronchial carcinoma described by Denny-Brown,1 and concurrently by Wyburn-Mason,2 has been the subject of reports by many later writers, including Henson, Russell, and Wilkinson3; Heathfield and Williams4 and Smith and Whitfield.5 Brain, Daniel, and Greenfield6 describe four cases of subacute cerebellar degeneration, three of which were found in association with carcinoma of the lung or ovary, and refer to two earlier cases described by Greenfield in 1934. That a wide range of unusual neurological disorders accompanies carcinoma with significant frequency is stressed by Henson and associates3 in their large series of 19 cases, which comprises 5 cases of cerebellar disease, 3 of sensory neuropathy, 3 of polyneuritis, and 8 of

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