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May 1959

Reticulum-Cell Sarcoma of Brain (Microglioma)

Author Affiliations


From Departments of Pathology and Neurosurgery, University of Pittsburgh School of Medicine and Veterans Administration Hospital.

AMA Arch NeurPsych. 1959;81(5):591-598. doi:10.1001/archneurpsyc.1959.02340170057004

Primary sarcoma of the brain is rare, having been estimated to comprise only 0.25% of all intracerebral neoplasms.1 The relative paucity of recorded cases, as well as the uncertain nosologic position of some glial cells, has apparently impeded their precise classification. The various appellations utilized for some intracerebral sarcomas with similar morphologic features and biologic behavior have further complicated the study of this group of neoplasms. The recent studies of Feigin and associates2,3 have satisfactorily demonstrated the vascular origin of that form of sarcomatous growth observed in some glioblastomas. However, much debate has occurred concerning that form of malignant mesoblastic cerebral neoplasm most commonly referred to as microglioma, or reticulum-cell sarcoma. Since the studies of Hortega4 and, subsequently, Dunning and Furth5 have indicated that the microglial cells represent the reticuloendothelial elements of the central nervous system, it would appear that much of the controversy concerning this

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