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May 1959

Analysis of Behavior Patterns Following Glutamic Acid Therapy

Author Affiliations

New York

From Columbia University College of Physicians and Surgeons, and the Division of Child Neurology, the Neurological Institute.

AMA Arch NeurPsych. 1959;81(5):649-657. doi:10.1001/archneurpsyc.1959.02340170115013

Introduction  This paper is the second in a series of three summarizing 13 years of experience with the glutamic acid treatment of mental retardation and behavior disorders. In the first report1 results of a controlled experiment are presented, comparing the effectiveness of glutamic acid, reserpine, and a placebo in producing intellectual and behavioral alterations and revealing the nature, as well as the degrees, of change obtained with each drug. Findings indicated considerable overlapping between action of the two drugs, with response broad in scope but highly individualized.As we pointed out, emphasis in the past few years has shifted away from a narrow fixation upon change or lack of change in the intelligence quotient following treatment because of the realization that mentation is only one aspect of much broader Gestalten involving a wide variety of behavioral manifestations. In contrast to former reports, the crux of the matter has recently

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