Margaret A.WinklerMDIndividualAuthorPhil B.FontanarosaMD, Senior EditorsIndividualAuthor
In Reply: In their previous
review article Dr Kendall and colleagues1 stated, "Of all
the therapies currently available for the prevention of sudden cardiac
death none is more established or more effective than the
beta-blockers."1 Exactly 1 month later, in the same
journal, a case-control study on antihypertensive therapy and the risk
of sudden death concluded, "that the use . . . of beta-blockers
is associated with an increased risk of sudden death compared with
other antihypertensive medications."2 These contradictory
reports provide a good example of how confusing and poorly established
the effects of β-blockers are with regard to primary prevention of
Messerli FH, Grossman E, Goldbourt U. β-Blockers as First-Line Agents for Hypertension in the Elderly—Reply. JAMA. 1999;281(2):131–133. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-2-jac80019
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