Copyright 1999 American Medical Association.
All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999
In Reply: Drs Blaufox and
Wassertheil-Smoller were investigators in the Trial of Antihypertensive
Interventions and Management (TAIM) Research Group.1 Their
study was a controlled clinical trial of overweight subjects with stage
1 hypertension. Patients were randomly allocated to receive 1 of 2
drugs (atenolol or chlorthalidone) or placebo and to a dietary
intervention (usual diet, weight loss diet, or a low-sodium,
high-potassium diet). This approach was very different from our study
design; we did not attempt dietary intervention as part of our study.
Furthermore, we performed classic plasma renin profiling using the
Laragh-Sealy method.2 We did not calculate a plasma renin
index. Although only men were in our study, we are not aware of any
specific sex differences in treatment response. The TAIM group reported
that black patients responded better to chlorthalidone plus weight
loss, whereas white patients responded better to atenolol plus weight
Preston RA, Materson BJ, Reda DJ, Williams DW. Renin Profiling to Predict Response to Antihypertensive Therapy—Reply. JAMA. 1999;281(9):793–794. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-9-jbk0303
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